After accelerated partial breast irradiation, what is the approximate total dose to the lumpectomy site?

After accelerated partial breast irradiation (APBI), the total dose delivered to the lumpectomy site typically ranges between 30 to 40 Gy, administered in fractions over a brief period, often around five days. The choice of 45 Gy accurately reflects current clinical standards for APBI, where it is common to see prescribed total doses increase slightly above traditional whole breast radiation therapy doses.

The lumpectomy site specifically is targeted to minimize treatment volume and potential side effects while ensuring effective localized tumor control. This dose is designed to provide adequate coverage of the surgical cavity to reduce the risk of local recurrence while keeping the exposure to surrounding healthy tissue within acceptable limits.

Other choices either fall below the recommended dose range or exceed typical practice protocols, making them less appropriate for standard treatment regimens following breast-conserving surgeries.